Straitsresearchtrendingreports: Isosorbide Market to Surpass USD 1,260.1 Million by 2033 Amid Surge in Demand for Sustainable Pharmaceuticals and Polymers

Straits Research — July 2025 | The global isosorbide market size reached USD 659.7 million in 2024 and is projected to expand to USD 1,260.1 million by 2033, registering a CAGR of 7.08% during the forecast period (2025–2033). The market is being propelled by a significant shift toward bio-based chemicals and the increasing incorporation of isosorbide derivatives into pharmaceutical formulations and polymer production.

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What is Isosorbide?

Isosorbide is a medication primarily used to prevent and treat angina pectoris (chest pain caused by heart disease), belonging to a class of drugs called organic nitrates. It works by relaxing and widening blood vessels (vasodilation), which reduces the heart's workload and oxygen demand while simultaneously improving blood flow and oxygen supply to the heart muscle. Commonly prescribed in two forms, isosorbide mononitrate (ISMN) and isosorbide dinitrate (ISDN), it is typically taken orally in regular tablets or capsules for prevention, or as a sublingual tablet or spray for rapid relief during an acute angina attack. Importantly, tolerance can develop with continuous use, and abrupt discontinuation should be avoided due to the risk of rebound angina. It is available only by prescription.

Isosorbide Uses Expanding in Modern Medicine

The pharmaceutical industry is emerging as a major consumer of isosorbide, driven by its role in developing cardiovascular medications. Key isosorbide uses include the formulation of isosorbide mononitrate and isosorbide dinitrate, both of which are extensively prescribed for conditions like angina pectoris and congestive heart failure due to their vasodilatory effects. In Spanish-speaking regions, these compounds are also referred to as isosorbide dinitrato, underlining their global significance.

Recent years have seen isosorbide being studied and integrated alongside well-known medications such as tramadol, carbamazepine, glipizide, baclofen, chlorthalidone, zetia, methylprednisolone, mirabegron, and solifenacin either in complementary roles or in combined therapies where vascular health and bioavailability are concerns.

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Market Segmentation Highlights

By Product Type:

Oil-Based Isosorbide
Water-Based Isosorbide
Silicone-Based Isosorbide

By Application:

Polyethylene Isosorbide Terephthalate (PEIT)
Polycarbonate
Isosorbide Polyesters (PIS)
Polyurethane
Isosorbide Diesters

By End-Use Industry:

Polymers & Resins
Pharmaceuticals
Additives
Personal Care & Cosmetics

Leading Market Players

Roquette Frères
Mitsubishi Chemical Corporation
Archer Daniels Midland Company
Novaphene
Samyang Biopharmaceuticals Corporation
Thermo Fisher Scientific
Merck KGaA
Par Pharmaceutical
Oakwood Products Inc.

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Regional Insights: Asia-Pacific Takes the Lead

Asia-Pacific

The Asia-Pacific isosorbide market remains the largest contributor globally. Countries such as India, China, and Japan are rapidly investing in green chemistry and bio-refinery technologies. India’s "Make in India" initiative and China’s sustainability policies are creating a supportive environment for bio-based chemical production.

North America

North America is forecasted to be the fastest-growing region, bolstered by robust pharmaceutical R&D, increasing demand for bio-polymers, and government support for low-carbon initiatives. The U.S. is at the forefront with active research on isosorbide’s integration with medications like solifenacin, glipizide, and carbamazepine to enhance absorption and reduce side effects.